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Willow L-5MTHF 60 capsules acne Muscular pain5 Methyltetrahydrofolate (5 MTHF) is the most active form of folic acid, the B group vitamin, also known generically as folate. Folate deficiencies have been linked with such health conditions as cancer, cardiovascular diseases and neurological abnormalities. What Does 5 MTHF Do? 5 MTHF (together with vitamin B12) functions as a methyl group donor in a range of metabolic and nervous system processes, making it vital to numerous metabolic pathways in